Results: Through searching the databases, the 137 ingredients of WDD that correspond to 938 targets and 4794 targets related to GAD were identified. Ultimately, these key targets and pathways were validated by in vivo experiments on GAD mice modeled by repeated restraint stress (RRS) and in vitro experiments on inflammatory factor stimulated BV-2 cells. Further, PPI network and KEGG enrichment were used to identify the key targets and pathways. Methods: The targets of WDD for the treatment of GAD were obtained by a search of online databases. ![]() Objective: The mechanism of Wendan Decoction (WDD) against Generalized Anxiety Disorder (GAD) was predicted by network pharmacology and validated by in vivo and in vitro experiments. *These authors contributed equally to this workĬorrespondence: Xin Zhao Yue-Han Song, Email ![]() Qi Jin 1 *, Jie Li 2 *, Guang-Yao Chen 1 *, Zi-Yu Wu, 3 Xiao-Yu Liu, 2 Yi Liu, 4 Lin Chen, 5 Xin-Yi Wu, 5 Yan Liu, 2 Xin Zhao, 2 Yue-Han Song 2ġGraduate School, Beijing University of Chinese Medicine, Beijing, 100029, People’s Republic of China 2School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, People’s Republic of China 3Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100007, People’s Republic of China 4Humanities School, Beijing University of Chinese Medicine, Beijing, 100029, People’s Republic of China 5Qihuang School, Beijing University of Chinese Medicine, Beijing, 100029, People’s Republic of China
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